Results
Treatment comparison and time to event for T/O versus tio by CID composite endpoint score
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There was a reduction in the risk of CID with T/O compared with tio in the overall patient population and in both patient subsets
Kaplan–Meier estimate of the probability of an event in patients treated with T/O versus tio in the overall patient population
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The Kaplan–Meier estimate shows that the time to an event is longer with T/O versus tio, with clear separation between the two treatment arms
Individual components of the composite endpoint: event rates and time to first event (25th percentile) in the total patient population
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Improvements in each component of the composite endpoint contributed to the delay in reaching CID with T/O versus tio
Abbreviations: CI, confidence interval; CID, clinically important deterioration; FEV1, forced expiratory volume in 1 second; HR, hazard ratio; SGRQ, St. George’s Respiratory Questionnaire; T/O, tiotropium/olodaterol; tio, tiotropium.