Results
- In Chinese patients, the mean age was 64.9 years old. Most patients were males (93.1%) and ex-smokers (74.3%), with a mean post-bronchodilator FEV1 of 40.8% predicted. A total of 25.3%, 48.4% and 26.3% out of 1322 patients presented with GOLD II, III and IV, respectively. More than 1/3 out of 1324 patients (43.8%) had ≥2 moderate to severe exacerbations in the previous year.
- Baseline demographics and clinical characteristics between Chinese patients with absolute BEC <300 and ≥300 cells/µL were comparable (Table 1).
- At baseline, the median (interquartile range [IQR]) absolute BEC in 1532 Chinese patients was 150 cells/µL (90–250 cells/µL). Overall, 1221 (79.7%) had an absolute BEC <300 cells/µL and 408 (26.6%) had <100 cells/µL; only 20.3% had an absolute BEC ≥300 cells/µL (Figure 1).
- In 11357 non-Chinese patients, the median (IQR) absolute BEC was 170 cells/µL (100–260 cells/µL) at baseline. The absolute BEC distribution of non-Chinese patients was similar to that of Chinese patients, i.e. 9007 (79.3%) non-Chinese patients had an absolute BEC <300 cells/µL and 2720 (23.9%) had <100 cells/µL; only 20.7% had an absolute BEC ≥300 cells/µL (Figure 1 and 2).
Table 1: Baseline demographic and clinical characteristics of Chinese patients
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Figure 1: Proportion of patients according to eosinophil count (cells/µL) in Chinese vs non-Chinese patients at baseline
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Figure 2: Distribution of blood eosinophil counts in Chinese vs non-Chinese patients at baseline
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