Moisés Selman,1 R Gisli Jenkins,2 Eric S White,3 Vincent Cottin,4 Yasuhiko Nishioka,5 Imre Noth,6 Antje Prasse,7 Jin Woo Song,8 Benjamin Strobel,9 German Leparc,9 Carina Ittrich,9 Claudia Diefenbach,10 Klaus B Rohr,10 Susanne Stowasser,10 Toby M Maher11 on behalf of the INMARK trial investigators

1Instituto Nacional de Enfermedades Respiratorias “Ismael Cosio Villegas”, Mexico City, Mexico; 2National Institute for Health Research Respiratory Biomedical Research Centre, City Campus, Nottingham University Hospital, Nottingham, UK; 3University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, Michigan, USA; 4Respiratory Diseases Department, National Reference Center for Rare Pulmonary Diseases, Respiratory Diseases Department, Louis Pradel Hospital, Claude Bernard Lyon 1 University, Lyon, France; 5Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan; 6Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, Virginia, USA; 7MHH Hannover Medical School, Department of Respiratory Medicine, Hannover, Germany; 8University of Ulsan College of Medicine, Asan Medical Center, Pulmonary and Critical Care Medicine, Seoul, South Korea; 9Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany; 10Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany; 11National Heart and Lung Institute, Imperial College London, UK and National Institute for Health Research Clinical Research Facility, Royal Brompton Hospital, London, UK

Introduction

  • Nintedanib is an approved treatment for IPF, which reduces the rate of decline in forced vital capacity.1
  • Nintedanib is an intracellular inhibitor of tyrosine kinases that has antifibrotic effects including inhibition of fibroblast proliferation, migration and differentiation and deposition of extracellular matrix.2,3
  • The INMARK trial investigated the effect of nintedanib on blood biomarkers that may be associated with the progression of IPF.4
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