Jamie L Todd,1,2 Megan L Neely,1,2 Robert Overton,1 Hillary Mulder,1 Jesse Roman,3 Joseph A Lasky,4 Joao de Andrade,5 Mridu Gulati,6 Howard Huang,7 Thomas B Leonard,8 Christian Hesslinger,9 Imre Noth,10 John A Belperio,11 Kevin R Flaherty,12 Scott M Palmer1,2 on behalf of the IPF-PRO Registry investigators
1Duke Clinical Research Institute, Durham, North Carolina, USA; 2Duke University Medical Center, Durham, North Carolina, USA; 3Jane and Leonard Korman Respiratory Institute, Philadelphia, Pennsylvania, USA; 4School of Medicine, Tulane University, New Orleans, Louisiana, USA; 5Vanderbilt University School of Medicine, Nashville, Tennessee, USA; 6Yale School of Medicine, New Haven, Connecticut, USA; 7Houston Methodist Hospital, Houston, Texas, USA; 8Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA; 9Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany; 10Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, Virginia, USA; 11David Geffen School of Medicine at UCLA, Los Angeles, California, USA; 12Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Introduction
- Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease with an unpredictable clinical course.
- Biomarkers that predict clinically relevant outcomes remain an unmet need.
- Prior work has demonstrated that patients with IPF have a unique peripheral blood proteome,1,2 thus proteomic profiling may identify targets for development of prognostic biomarkers.